|
|
| |
 |
产品展示 |
您现在的位置是：首页 >> 产品展示 >> 原料药 |
|
|
| |
| MK-4305 |
 |
| |
Suvorexant MK 4305; MK-4305; MK4305 CAS 1030377-33-3
Suvorexant (MK-4305)是OX受体拮抗剂，对OX1和OX2受体的Ki分别为0.55 nM和0.35 nM
Suvorexant的生物活性
Suvorexant (MK-4305) is a potent dual OX receptor antagonist with Ki of 0.55 nM and 0.35 nM for OX1 receptor and OX2 receptor, respectively.
IC50 value: 0.55/0.35 nM(Ki, OX1/2) [1]
Target:OX1R; OX2R
in vivtro:
in vivo: Suvorexant has excellent passive permeability and oral bioavailability, and induces favorable sleep effects in rats [1]. In addition, suvorexant significantly and dose-dependently reduces locomotor activity and promotes sleep in rats (10, 30, and 100 mg/kg), dogs (1 and 3 mg/kg), and rhesus monkeys (10 mg/kg) [2].
化学信息
| 分子量 |
450.92 |
储存条件 |
参考CoA中推荐的条件进行储存。 |
| 分子式 |
C23H23ClN6O2 |
| CAS号 |
1030377-33-3 |
| 溶剂/溶解度 |
DMSO 10 mg/ml; Water <1 mg/ml | |
| 返回上一页 |
|
| |
|
